A buildup of fatty plaques in your arteries, or atherosclerosis can damage your blood vessels and heart. Plaque buildup causes narrowed or blocked blood vessels that can lead to a heart attack, chest pain (angina), or stroke.
Coronary artery disease symptoms may be different for men and women. For instance, men are more likely to have chest pain. Women are more likely to have other signs and symptoms along with chest discomforts, such as shortness of breath, nausea, and extreme fatigue.